Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function
US8367374B2 · kind B2 · utility
5Cited by
3References
33Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 2004 |
| Grant date | Feb 5, 2013 |
| Priority date | — |
| Expiry date | Mar 28, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/05
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.