Patent · US Active

Pharmaceutical composition which improves in vivo gene transfer

US8367631B2 · kind B2 · utility

49Cited by

2References

10Claims

0Family size

Assignee

Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventor

Bruno Pitard · Rezé, FR

Key dates

Filing date	Mar 15, 2010
Grant date	Feb 5, 2013
Priority date	—
Expiry date	Mar 15, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A pharmaceutical composition, including at least one nucleic acid, a Tyrode's medium having 140 mM NaC1, 6 mM KC1, 3 mM CaC12, 2 mM MgC12, 10 mM Hepes, pH 7.4, and 10 mM glucose; and a tetrafunctional copolymer of formula (I):where x and y represent, independently of one another, an integer of between 1 and 500, the tetrafunctional copolymer is in a form of a mineral salt wherein said tetrafunctional copolymer is in a cationic form. The compound of formula (I) has a molecular weight of between 1,000 and 25,000 g/mol and an EO/PO ratio of 0.8 to 1.2.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.