Patent · US Active

Hydroxyapatite-targeting poly(ethylene glycol) and related polymers

US8372422B2 · kind B2 · utility

1Cited by
13References
17Claims
0Family size

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Inventors

Key dates

Filing dateOct 6, 2010
Grant dateFeb 12, 2013
Priority date—
Expiry dateApr 22, 2031

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC08L2203/02
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.