Method for inhibiting adhesion formation using an improved placental tissue graft
US8372438B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 2012 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Aug 7, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T156/1039
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.