Method for detecting misfolded proteins and prions
US8372593B2 · kind B2 · utility
4Cited by
27References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 2006 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Feb 8, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2828
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise selectively capturing and separating complexes of peptide and conformationally altered protein from substances that interfere with detection of such complexes, and preferably amplification of the detection signal b addition of a second double-labeled peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.