Method and apparatus for measuring changes in cell volume
US8372600B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 2009 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Apr 11, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2015/1029
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The voltage induced by said current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The voltage induced by said current flow is measured. The first induced voltage result and the second induced voltage result are used in conjunction with known voltages induced by such current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.