Production of four carbon alcohols using improved strain
US8372612B2 · kind B2 · utility
39Cited by
3References
13Claims
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Key dates
| Filing date | Dec 9, 2008 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Dec 4, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone biosynthetic pathway are useful for production of butanol or 2-butanone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.