Spray dried formulation
US8372836B2 · kind B2 · utility
5Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 8, 2007 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Nov 4, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions comprising a poorly water soluble ionizable drug, a cationic species and a dispersion polymer are disclosed, together with a process for forming the compositions. The neutral form of the drug has (i) a solubility of less than 1 mg/ml, in aqueous solution at a pH between 6 and 7, (ii) a solubility of less than 20 mg/mL in a volatile organic solvent, and (iii) an acidic pKa value of greater than 5. At least 90 wt % of the drug in the solid dispersion being in a non-crystalline form. The drug, the cationic species, and the dispersion polymer constitute at least 80 wt % of the solid dispersion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.