Patent · US Active

Bipartite inhibitors of bacterial RNA polymerase

US8372839B2 · kind B2 · utility

3Cited by

6References

42Claims

0Family size

Assignee

Rutgers, the State University of New Jersey · US

Inventors

Richard H. Ebright · New Brunswick, US
Dongye Wang · Edison, US

Key dates

Filing date	Nov 4, 2006
Grant date	Feb 12, 2013
Priority date	—
Expiry date	Dec 27, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention provides a compound having a structural formula (I): X-α-Y, wherein X is an moiety that binds to the Rif pocket of a bacterial RNA polymerase, Y is a moiety that binds to the secondary channel of a bacterial RNA polymerase, and α is a linker. The compound can act as an inhibitor of bacterial RNA polymerase. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.