Carboline derivatives useful in the inhibition of angiogenesis
US8372860B2 · kind B2 · utility
11Cited by
39References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 2, 2010 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Dec 12, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/515
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.