Sphingosine kinase type 1 inhibitors, compositions and processes for using same
US8372888B2 · kind B2 · utility
22Cited by
3References
5Claims
0Family size
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Key dates
| Filing date | Apr 29, 2009 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Apr 29, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/092
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are novel compositions which uniquely inhibit sphingosine kinase Type 1 (SphK1) and which are useful in a number of applications including killing or damaging cancer cells, inducing apoptosis, inhibiting growth, metastasis and development of chemoresistance in cancer cells, leukemia, increasing the effectiveness of anti-cancer agents, attenuating immune reactivity, inhibiting survival signaling in cancer cells, and reducing symptoms of multiple sclerosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.