Phage display libraries of human VH fragments

US8372954B2 · kind B2 · utility

Assignee

• National Research Council of Canada · CA

Inventors

• Jamshid Tanha · Ottawa, CA
• Joycelyn Entwistle · Winnipeg, CA
• Saran Narang · Ottawa, CA
• Michael Dan · Markham, CA
• Colin Roger Mackenzie · Ottawa, CA
• Howard Kaplan · Winnipeg, CA

Key dates

• Filing date: Dec 21, 2001
• Grant date: Feb 12, 2013
• Expiry date: Jun 23, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/735
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Phage display libraries are taught in which the recombinant phage population displays a plurality of potential binding fragments having preferred characteristics of solubility and/or intermolecular interaction. Also taught are methods of biasing display libraries to produce variants which more closely approximate the preferred characteristics of the parental binding fragment.