Ribonucleotide reductase inhibitors and methods of use
US8372983B2 · kind B2 · utility
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Key dates
| Filing date | Feb 1, 2012 |
| Grant date | Feb 12, 2013 |
| Priority date | — |
| Expiry date | Feb 1, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/99
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
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