Patent · US Active

Reconstituted human breast tumor model

US8373017B2 · kind B2 · utility

2Cited by

2References

6Claims

0Family size

Assignee

AVEO Pharmaceuticals, Inc. · US

Inventors

Min Wu · Beijing, CN
Charlotte Kuperwasser · Boston, US
Murray Robinson · Malibu, US

Key dates

Filing date	Dec 6, 2005
Grant date	Feb 12, 2013
Priority date	—
Expiry date	Oct 4, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2799/027
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Reconstituted human breast tumor models are disclosed. The models, which are incorporated into mice, provide actual tumors that arise spontaneously, thereby mimicking naturally occurring breast cancer. The tumors are genetically human, because they arise from human mammary tissues that develop from human mammary epithelial cells implanted into host mice. Prior to implantation, the mammary epithelial cells are genetically modified to contain either: (a) a recombinant human oncogene and an SV40er; or (b) a recombinant human oncogene, a transgene or shRNA that inhibits the p53 pathway, and a transgene or shRNA that inhibits the Rb pathway.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.