Nano- and mesosized particles comprising an inorganic core, process and applications thereof

US8377469B2 · kind B2 · utility

Assignee

• BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY · IL

Inventors

• Jacob Zabicky · Beer Sheva, IL
• Charles Linder · Rehovot, IL
• Sarina Grinberg · Meitar, IL
• Eliahu Heldman · Rehovot, IL

Key dates

• Filing date: Jan 2, 2006
• Grant date: Feb 19, 2013
• Expiry date: Nov 11, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1277
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.