Microfluidic device having stable static gradient for analyzing chemotaxis
US8377685B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 7, 2008 |
| Grant date | Feb 19, 2013 |
| Priority date | — |
| Expiry date | Sep 24, 2031 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2400/0472
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A microfluidic method and device for testing and analyzing chemotaxis by providing a stable, static fluid gradient. The device includes a sink reservoir for receiving biological cellular material and a source reservoir for receiving a chemoattractant. The biological cellular material migrates through a low fluid volume microfluidic gradient channel located between the source and sink reservoirs. The fluid in the gradient channel is static and stable due to a high fluid volume closed circuit bypass microfluidic channel also in fluid communication with the source and sink reservoirs, whereby the bypass channel relieves any pressure differential imparted across the gradient channel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.