Polymeric prodrug with a self-immolative linker

US8377917B2 · kind B2 · utility

Assignee

• Complex BioSystems GmbH · DE

Inventors

• Ulrich Hersel · Heidelberg, DE
• Harald Rau · Würzburg, DE
• Robert Schnepf · Dossenheim, DE
• Dirk Vetter · Heidelberg, DE
• Thomas Wegge · Heidelberg, DE

Key dates

• Filing date: Mar 22, 2005
• Grant date: Feb 19, 2013
• Expiry date: Aug 27, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A cascade carrier linked prodrug is described which comprises a biologically active moiety and a masking group having at least one nucleophile and being distinct from the carrier.