Oxadiazole derivatives for the treatment of diabetes

US8377975B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Markus Klein · Weiterstadt, DE
• Norbert Beier · Reinheim, DE
• Florian Lang · Gilching, DE

Key dates

• Filing date: Jul 9, 2009
• Grant date: Feb 19, 2013
• Expiry date: Aug 4, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel oxadiazole derivatives of the formula (I), in which R, R′, Y, X1, X2 and X3 have the meanings indicated in claim 1, are kinase inhibitors and can be used for the treatment of diseases and conditions such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, in general in all types of fibroses, inflammatory processes, tumours and tumour diseases.