High affinity HIV T cell receptors

US8378074B2 · kind B2 · utility

Assignee

• IMMUNOCORE LIMITED · GB

Inventors

• Bent Karsten Jakobsen · Abingdon, GB
• Yi Li · Sunnyvale, US
• Steven Mark Dunn · Abingdon, GB
• Peter Eamon Molloy · Woodstock, GB

Key dates

• Filing date: Mar 29, 2006
• Grant date: Feb 19, 2013
• Expiry date: Dec 2, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides TCRs having high affinity. The TCR binds to SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 with a KD of less than or equal to 1 μM and/or an off-rate (koff) of 1×10−3 S−1 or slower using Surface Plasmon Resonance. The TCRs are non-native, isolated or recombinant. The TCRs are useful, either alone, or with a therapeutic agent, for targeting HIV infected cells that present the SLYNTVATL (SEQ ID NO:16)-HLA-A*0201 complex.