Pyrazole-based thyroid receptor compounds

US8378118B2 · kind B2 · utility

Assignee

• Torrent Pharmaceuticals Limited · IN

Inventors

• Laxmikant Chhipa · Mahesana, IN
• Shitalkumar Zambad · Sayla, IN
• Ramesh Gupta · Prospect, US
• Davinder Tuli · Gandhinagar, IN
• Ashok Kasundra · Sayla, IN
• Siralee Munshi · Sayla, IN
• M. Amir Siddiqui · Sayla, IN
• Subrat Kumar Bhattamisra · Sayla, IN
• C. Dutt · Sayla, IN
• Vijay Chauthaiwale · Gandhinagar, IN

Key dates

• Filing date: Jan 10, 2012
• Grant date: Feb 19, 2013
• Expiry date: Jan 10, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses a novel thyroid like compounds of formula (I), wherein R1 R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition containing such compounds and use of such compounds and composition as medicament. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions such as obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.