Hydroxylated contrast enhancement agents

US8378134B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Brian James Grimmond · Clifton Park, US
• Michael Todd Luttrell · Clifton Park, US
• Jeannette Christine DePuy · Burnt Hills, US
• Mary Elizabeth Spilker · Village of La Jolla, US
• Michael James Rishel · Saratoga Springs, US

Key dates

• Filing date: Sep 30, 2009
• Grant date: Feb 19, 2013
• Expiry date: Sep 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C229/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure Iwherein R1 is independently at each occurrence a hydroxy group, a C1-C3hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.