Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
US8378137B2 · kind B2 · utility
4Cited by
8References
25Claims
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Key dates
| Filing date | Aug 11, 2011 |
| Grant date | Feb 19, 2013 |
| Priority date | — |
| Expiry date | Aug 11, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/416
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.