Tissue adhering compositions
US8383144B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 17, 2009 |
| Grant date | Feb 26, 2013 |
| Priority date | — |
| Expiry date | Dec 17, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2017/0065
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.