Patent · US Active

Precircle probe nucleic acid amplification methods

US8383348B2 · kind B2 · utility

1Cited by

50References

1Claims

0Family size

Assignee

Board of Trustees of the Leland Stanford Junior University · US

Inventors

Thomas Willis · San Francisco, US
Paul Hardenbol · San Francisco, US
Maneesh Jain · Santa Clara, US
Viktor Stolc · Cupertino, US
Mostafa Ronaghi · Menlo Park, US
Ronald W. Davis · Menlo Park, US

Key dates

Filing date	Aug 9, 2011
Grant date	Feb 26, 2013
Priority date	—
Expiry date	Aug 9, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/686
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.