Transformant and method for production of non-natural antibiotic
US8383392B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Sep 12, 2008 |
| Grant date | Feb 26, 2013 |
| Priority date | — |
| Expiry date | May 12, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed is a transformant prepared by introducing a ketoreductase gene involved in the biosynthesis of L-epivancosamine into an actinobacterium originally capable of producing daunorubicin. Also disclosed is a process of efficiently producing a non-natural daunorubicin derivative using the transformant. The transformant is capable of efficiently producing a non-natural daunorubicin derivative such as epidaunorubicin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.