Method and system for the production of cells and cell products and applications thereof

US8383397B2 · kind B2 · utility

Assignee

• BIOVEST INTERNATIONAL, INC. · US

Inventors

• Robert J. Wojciechowski · Forest Lake, US
• Darrell P. Page · Walnut, US
• Karl Patrick Bongers · Coon Rapids, US
• SCOTT WANIGER · Andover, US
• Beverly Norris · Blaine, US
• Mark Hirschel · Blaine, US
• Thiem Chan Duong Wong · Brooklyn Park, US
• Martin Peder Crep · Windom, US
• Michael J. Gramer · Stanford, US
• Grant Adams · Anoka, US

Key dates

• Filing date: Nov 20, 2008
• Grant date: Feb 26, 2013
• Expiry date: Apr 29, 2031

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F04B43/1292
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A cell culture system for the production of cells and cell derived products includes a reusable instrumentation base device incorporating hardware to support cell culture growth. A disposable cultureware module including a cell growth chamber is removably attachable to the instrumentation base device. The base device includes microprocessor control and a pump for circulating cell culture medium through the cell growth chamber. The cultureware module is removably attached to the instrumentation base device. Cells are introduced into the cell growth chamber and a source of medium is fluidly attached to the cultureware module. Operating parameters are programmed into the microprocessor control. The pump is operated to circulate the medium through the cell growth chamber to grow cells or cell products therein. The grown cells or cell products are harvested from the cell growth chamber and the cultureware module is then disposed.