Peptide-coated nanoparticles with graded shell compositions

US8383423B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Shimon Weiss · Pinole, US
• James Tsay · Los Angeles, US
• Fabien Pinaud · Los Angeles, US
• Soren Doose · Bielefeld, DE

Key dates

• Filing date: Mar 29, 2011
• Grant date: Feb 26, 2013
• Expiry date: Mar 29, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2991
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A peptide-coated nanoparticle that includes a nanocrystal surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The nanocrystal core and graded shell are optionally annealed with ultra violet radiation prior to and/or after attachment of the peptide(s).