Altered peptide ligand derived from HSP60 and pharmaceutical compositions
US8383771B2 · kind B2 · utility
1Cited by
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2Claims
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Key dates
| Filing date | Sep 22, 2005 |
| Grant date | Feb 26, 2013 |
| Priority date | — |
| Expiry date | Jun 8, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.