Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions

US8388935B2 · kind B2 · utility

Assignee

• Cedars Sinai Medical Center · US

Inventors

• Henry Lin · Hsinchu, TW
• Mark Pimentel · Los Angeles, US

Key dates

• Filing date: Dec 9, 2011
• Grant date: Mar 5, 2013
• Expiry date: Dec 9, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.