Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma

US8388972B2 · kind B2 · utility

Assignees

• Advanced Accelerator Applications SA · US
• Istituto Nazionale per lo Studio e la Cura dei Tumori · IT

Inventors

• Franck Martin · Montpellier, FR
• Margherita Cattozzo · L'Aquila, IT
• Giovanni Maurizi · L'Aquila, IT
• Vito Di Cioccio · L'Aquila, IT
• Mariangela Figini · Milano, IT
• Silvana Canevari · Segrate, IT

Key dates

• Filing date: Sep 12, 2007
• Grant date: Mar 5, 2013
• Expiry date: May 1, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRα), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences: —RASESVSFLGINLIH (SEQ ID NO: 3), —QASNKDT (SEQ ID NO: 4), —LQSKNFPPYT (SEQ ID NO: 5), and wherein the constant region of said light chain is a kappa constant region.