Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules

US8388984B2 · kind B2 · utility

Assignees

• Da Volterra · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS (APHP) · FR
• UNIVERSITÉ PARIS DIDEROT—PARIS 7 · FR
• UNIVERSITÉ PARIS CITÉ · FR

Inventors

• Helene-Celine Huguet · Dijon, FR
• Antoine Andremont · Malakoff, FR
• Nicolas Tsapis · Paris, FR
• Elias Fattal · Paris, FR

Key dates

• Filing date: Sep 14, 2011
• Grant date: Mar 5, 2013
• Expiry date: Sep 14, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions which deliver adsorbents, alone or in combination with active drug “degrading molecules,” in a site-specific manner to the intestine, and which eliminate or at least lower the concentration of residual unwanted material within the intestine, and methods of treatment using the compositions, are disclosed. The compositions are ideally designed to specifically release the adsorbents in a programmed manner at a specific site of the intestinal tract. Programmed delivery prevents adsorbents from interfering with the normal absorption process of a given molecule after oral absorption, until it reaches the lower part of the small intestine. The compositions can be used to adsorb, and therefore remove, any residual drug, metabolite thereof, or bacterial toxin after oral or parenteral administration which would otherwise cause adverse effects in the lower intestine and/or colon.