Preparation for restenosis prevention

US8389043B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Ulrich Speck · Berlin, DE
• Bruno Scheller · Saarburg, DE

Key dates

• Filing date: Jul 13, 2010
• Grant date: Mar 5, 2013
• Expiry date: Jul 13, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/416
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.