Modulators of aldehyde dehydrogenase and methods of use thereof

US8389522B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Daria Mochly-Rosen · Menlo Park, US
• Che-Hong Chen · Fremont, US
• Wenjin Yang · Foster City, US

Key dates

• Filing date: Oct 19, 2009
• Grant date: Mar 5, 2013
• Expiry date: May 18, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.