Biologically active antibodies recognizing a cell surface molecule selectively expressed on living mouse natural type one (I) interferon producing cells
US8389694B2 · kind B2 · utility
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Key dates
| Filing date | Nov 23, 2004 |
| Grant date | Mar 5, 2013 |
| Priority date | — |
| Expiry date | Sep 3, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An isolated and characterized monoclonal antibody (“440c”) prepared by immunizing Wistar/CRL rats subcutaneously with purified rat bone marrow IPC, fusing popliteal lymph nodes of the rats with SP2/0 myeloma spleen cells and differentially selecting for hybridome supernatants that successfully stain bone marrow derived IPC and fractions thereof using CD11c+ spleen cells and, differentially selecting for hybridoma supernatants from the CD11c+ spleen cells that successfully stain only CD 11 c+/Ly6c+/CD 11 b−/B220+ splenocytes to provide the monoclonal antibody.
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