Process for the synthesis of quetiapine
US8389716B2 · kind B2 · utility
4Cited by
0References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 30, 2009 |
| Grant date | Mar 5, 2013 |
| Priority date | — |
| Expiry date | Aug 25, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.