Modulators of retinoid-related orphan receptor gamma
US8389739B1 · kind B1 · utility
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9Claims
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Key dates
| Filing date | May 24, 2011 |
| Grant date | Mar 5, 2013 |
| Priority date | — |
| Expiry date | May 24, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J21/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (RORγ) activity. This modulation has numerous effects, including inhibition of TH-17 cell function and/or TH-17 cell activity, and inhibition of re-stimulation of TH-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of RORγ results in stimulation of TH-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.