Methods and compositions comprising novel cationic lipids

US8389768B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Leaf Huang · Durham, US
• Yunching Chen · Boston, US
• Joyeeta Sen · Narayanpur, IN
• Surendar Reddy Bathula · Darsi, IN
• Sumio Chono · Otofuke, JP
• Shyh-Dar Li · Gongguan, TW
• Michael Hackett · Chapel Hill, US

Key dates

• Filing date: May 1, 2009
• Grant date: Mar 5, 2013
• Expiry date: Nov 28, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/88
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.