Drug delivery vehicle that mimics viral properties
US8394391B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Aug 31, 2007 |
| Grant date | Mar 12, 2013 |
| Priority date | — |
| Expiry date | Jun 28, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/167
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A drug delivery vehicle for targeted delivery of a drug mimics viral properties of size, capsid-like protein capsule, cell-specific entry, toxin release, destruction of infected cells, and migration to neighboring cells. This vehicle, termed a virogel, contains a hydrophobic polymeric core, a hydrophilic inner shell, a hydrophilic outer shell, and a ligand. An illustrative drug-loaded virogel includes poly(L-histidine-co-phenylalanine) as the core, doxorubicin loaded in the core, polyethylene glycol as the inner shell, bovine serum albumin as the outer shell, and folic acid as the ligand.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.