Identification of fetal DNA and fetal cell markers in maternal plasma or serum
US8394582B2 · kind B2 · utility
0Cited by
19References
15Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 5, 2004 |
| Grant date | Mar 12, 2013 |
| Priority date | — |
| Expiry date | Jun 24, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the identification of fetal specific nucleic acids and fetal cell markers in maternal plasma or serum. In particular, the present invention relates to methods which rely on the analysis of polymorphic alleles of a population to determine an allele which is possessed by the fetus but absent from the mother. Fetal specific alleles identified using the methods of the invention can be used to quantify fetal DNA from maternal plasma or serum. In addition, antigens encoded by alleles identified using the methods of the invention can be targeted in methods of isolating or detecting fetal cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.