Tyrosine kinome

US8394598B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Alberto Bardelli · Baltimore, US
• Will Parsons · Ellicott City, US
• Victor Velculescu · Dayton, US
• Kenneth W. Kinzler · Baltimore, US
• Bert Vogelstein · Baltimore, US

Key dates

• Filing date: Feb 15, 2010
• Grant date: Mar 12, 2013
• Expiry date: Jan 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in -20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.