Methods, compounds and compositions with genotype selective anticancer activity
US8394742B2 · kind B2 · utility
0Cited by
2References
16Claims
0Family size
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Key dates
| Filing date | Apr 14, 2006 |
| Grant date | Mar 12, 2013 |
| Priority date | — |
| Expiry date | May 25, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.