7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof

US8394787B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Ahmed Abouabdellah · Paris, FR
• Nathalie Chereze · Paris, FR
• Aude Fayol · Paris, FR
• Alistair Lochead · Moissac, FR
• Mourad Saady · Paris, FR
• Julien Vache · Paris, FR
• Philippe Yaiche · Paris, FR

Key dates

• Filing date: May 11, 2010
• Grant date: Mar 12, 2013
• Expiry date: May 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are a number from 0 to 3, provided that m+n≦7 and that o+p≦7; A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a —O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group and the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group; R4 is an optionally substituted 5-membered heterocyclic compounds; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.