Controlled release ion channel modulator compositions and methods for the treatment of otic disorders

US8399018B2 · kind B2 · utility

Assignees

• OTONOMY, INC. · US
• The Regents of the University of California · US

Inventors

• Jay Lichter · Rancho Santa Fe, US
• Benedikt Vollrath · San Diego, US
• Sergio G. Duron · San Diego, US
• Carl Lebel · Malibu, US
• Fabrice Piu · San Diego, US
• Qiang Ye · San Diego, US
• Luis A. Dellamary · San Marcos, US
• Andrew M. Trammel · Olathe, US
• Michael Christopher Scaife · Pittsburgh, US
• Jeffrey P. Harris · Village of La Jolla, US

Key dates

• Filing date: Jul 21, 2009
• Grant date: Mar 19, 2013
• Expiry date: May 27, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for the treatment of otic disorders with ion channel modulators. In these methods, the ion channel modulator compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the ion channel modulator compositions and formulations onto the auris interna target areas, or via perfusion into the auris interna structures.