Preparation of poly(ethylene oxide)-coated nanoparticles of maghemite
US8399021B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Feb 7, 2007 |
| Grant date | Mar 19, 2013 |
| Priority date | — |
| Expiry date | May 17, 2029 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01F1/0054
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a material consisting of an aqueous dispersion of PEG-coated nanoparticles of maghemite. The process for preparing said material consists in polymerizing ethylene oxide in the presence of nanoparticles of maghemite in an aqueous dispersion. The polymerization is initiated using reactive groups which are capable of initiating the polymerization of ethylene oxide without the addition of a catalyst, and which are attached to the nanoparticles of maghemite by means of a coupling agent comprising an alkoxysilyl group and one or more of said reactive groups. Applications: contrast agent for MRI.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.