Polyamine modified particles

US8399025B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Krishnendu Roy · Austin, US
• Sudhir Kasturi · Austin, US

Key dates

• Filing date: Jun 6, 2005
• Grant date: Mar 19, 2013
• Expiry date: Feb 26, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2300/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer of formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.