Method of manufacturing a tissue-engineered prosthesis
US8399243B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 1, 2006 |
| Grant date | Mar 19, 2013 |
| Priority date | — |
| Expiry date | Aug 22, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.