Chemical linkers and conjugates thereof
US8399403B2 · kind B2 · utility
1Cited by
121References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 2, 2009 |
| Grant date | Mar 19, 2013 |
| Priority date | — |
| Expiry date | May 10, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.