HSP90 inhibitor

US8399464B2 · kind B2 · utility

Assignee

• NIPPON KAYAKU KABUSHIKI KAISHA · JP

Inventors

• Hiroshi Kuramochi · Tokyo, JP
• Setsuko Niitsuma · Tokyo, JP
• Masaharu Nakamura · Kawasaki, JP
• Yoshitaka Sato · Tsukuba, JP
• Seiichi Saito · Kashiwa, JP
• Arihiro Tomura · Tokyo, JP
• Yuh-ichiro Ichikawa · Tokyo, JP
• Yousuke Kasuga · Tokyo, JP

Key dates

• Filing date: Mar 8, 2006
• Grant date: Mar 19, 2013
• Expiry date: Jul 23, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a triazole derivative(s) represented by the general formula (1) below or a pharmacologically acceptable salt(s) thereof. Also disclosed are a prodrug(s) of such a triazole derivative(s) and an HSP90 inhibitor(s) containing any one of them as an active constituent. (1) (In the formula, X represents a halogen atom, an optionally substituted alkyl group, an optionally substituted alkynyl group or the like; Y represents a mercapto group, a hydroxyl group, an optionally substituted sulfonyl group, an optionally substituted amino group or the like; and R represents an optionally substituted aryl or alkyl group or the like.)