Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same

US8399471B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Santiago Figueroa Perez · Leverkusen, DE
• Peter Kolkhof · Wuppertal, DE
• Lars Bärfacker · Oberhausen, DE
• Ingo Flamme · Bergneustadt, DE
• Karl-Heinz Schlemmer · Wuppertal, DE
• Alexander Kuhl · Hagen, DE
• Rolf Grosser · Schwandorf, DE
• Klaus Münter · Mannheim, DE
• Andreas Knorr · Erkrath, DE

Key dates

• Filing date: May 25, 2007
• Grant date: Mar 19, 2013
• Expiry date: May 5, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to novel aryl- or heteroaryl-substitued pyrido[2,3-d] pyrimidines of formula (I), pharmaceuitical compositions of the same, and a process for their preparation. Formula(I) is:wherein Ar is an aryl or heteroaryl substituent, and R1, R2, R3, Ar, D, and E are as defined in the specification. Compounds and compositions of the present invention can be used in the treatment and/or prophylaxis of various disorders in humans and animals, including aldosteronism, high blood pressure, chronic heart failure, the sequelae of a myocardial infarction, cirrhosis of the liver, renal failure, and stroke.