6-substituted isoquinolines and isoquinolinones

US8399482B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Oliver Plettenburg · Kelkheim, DE
• Katrin Lorenz · Frankfurt am Main, DE
• Matthias Loehn · Frankfurt am Main, DE
• John Weston · Frankfurt am Main, DE
• Heinz-Werner Kleemann · Bischofsheim, DE

Key dates

• Filing date: Dec 16, 2010
• Grant date: Mar 19, 2013
• Expiry date: Dec 16, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 6-substituted isoquinoline and isoquinolinone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.